Psychedelic substances have long fascinated researchers and the public alike for their ability to induce profound alterations in perception, cognition, and emotions. As our understanding of these substances deepens, new models are emerging to explain how psychedelics affect the brain and produce their unique effects. One such model is the REBUS (Relaxed Beliefs Under Psychedelics) and the Anarchic Brain hypothesis, which offers a unified framework for understanding the brain action of psychedelics.

In a groundbreaking article published in the journal "Pharmacological Reviews," Dr. Robin Carhart-Harris and Prof. Karl Friston propose the REBUS and the Anarchic Brain model to explain how psychedelics influence the brain's neural architecture and facilitate more flexible and adaptable thought patterns. According to the model, the hierarchical organization of the brain is temporarily disrupted under the influence of psychedelics, resulting in a "relaxation" of high-level beliefs and an increased influence of lower-level sensory information. This relaxation of beliefs allows for the emergence of novel insights, experiences, and perspectives, which may be therapeutic for individuals suffering from various mental health conditions.

The REBUS model and the Anarchic Brain hypothesis draw on principles from neuroscience, psychology, and computational modeling to provide a comprehensive framework for understanding the effects of psychedelics. This model has significant implications for the study of psychedelics in both clinical and research settings, as it helps to explain how these substances can promote psychological flexibility, enhance creativity, and facilitate therapeutic breakthroughs.

What are your thoughts on the REBUS and Anarchic Brain model? Do you think it provides a compelling explanation for the effects of psychedelics on the brain, or are there alternative models that you find more convincing? Share your thoughts and experiences in the comments below.

References:

Carhart-Harris, R. L., & Friston, K. J. (2019). REBUS and the Anarchic Brain: Toward a Unified Model of the Brain Action of Psychedelics. Pharmacological Reviews, 71(3), 316–344. https://doi.org/10.1124/pr.118.017160

Disclaimer:

Neuro-psychedelic does not encourage the recreational use of psychedelics. While research has shown promising results for the therapeutic use of psychedelics, they are powerful, mind-altering substances that should only be used in a safe and controlled setting. It is important to work with qualified professionals and to fully understand the potential risks and benefits before undergoing any psychedelic-assisted therapy. If you or someone you know is struggling with mental health issues, it is important to seek support from a qualified mental health professional.