Classic Psychedelics
Classic or “serotonergic” psychedelics, such as LSD, DMT, psilocybin, and mescaline, are the substances that are typically associated with the term "psychedelics" as they primarily act as agonists at the serotonin 2A receptor, leading to the characteristic psychedelic experience. Explore each of the classic psychedelics below.
Ibogaine, a psychoactive compound derived from the African iboga shrub, is notable for its use in addiction treatment and spiritual ceremonies. Traditionally utilized in rites of passage and healing rituals in West African cultures, ibogaine is recognized for its ability to induce intense, introspective experiences that can be pivotal in breaking cycles of substance dependency. Ibogaine has been the subject of growing interest for treating opioid addiction and withdrawal.
LSD is a powerful psychedelic substance renowned for its therapeutic applications and profound effects on consciousness. Similar to psilocybin, LSD exhibits therapeutic potential in addressing mental health conditions such as depression, anxiety, PTSD, and addiction disorders. MM120,a tartrate salt form of lysergide has received breakthrough therapy status by the FDA for treating anxiety.
Mescaline, a psychoactive alkaloid found primarily in the peyote cactus, is known for its potent psychedelic effects. Traditionally used in Native American spiritual rituals, it facilitates deeply introspective and transformative experiences. Mescaline's influence extends to the realms of personal insight and healing, making it a significant substance in various cultural and therapeutic practices.
DMT is a psychedelic compound found in various plants and animals, including humans. Known for inducing intense visual and emotional experiences, DMT is celebrated for its profound impact on consciousness and spiritual exploration. DMT's use in ayahuasca ceremonies, guided by shamans, is deeply rooted in the spiritual traditions of the Amazonian tribes.
Psilocybin, found in "magic" mushrooms, is recognized for its therapeutic potential in treating conditions like depression, anxiety, PTSD, anorexia nervosa, OCD, and substance dependencies. Its psychoactive properties facilitate profound psychological insights and emotional processing, making it a valuable tool in various healing and mental health contexts. Psilocybin has a long history of use in spiritual and traditional practices, now increasingly acknowledged in modern therapeutic settings.
Bufotenine is a potent psychoactive compound extracted from plants and the secretions of amphibians such as the Colorado River toad. Revered in spiritual ceremonies for centuries, it induces intense introspection and visionary experiences. Bufotenine is known to be less visual than other psychedelics.